Blue Lock follows Yoichi Isagi, a talented high school soccer player who joins a revolutionary training program after Japan's national team fails to qualify for the World Cup. The program, known as Blue Lock, aims to create the world's best striker by pitting 300 forwards against each other in intense matches and challenges.

Participants must confront their skills, ambitions, and rivalries as they strive to outdo one another. The series delves into themes of self-discovery, competition, and the drive to win, all while showcasing thrilling soccer action and character development. As Isagi navigates the challenges of Blue Lock, he learns what it truly means to be a top player and the sacrifices required to achieve greatness.